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The Pbserum cosmeceuticals line contains as active principles the first recombinant enzymes of bacterial origin, with proven efficacy, which guarantees visible and prolonged results in a short time and from the first application. This innovative treatment is the result of long years of biotechnological research in the cosmetic and pharmaceutical industries, which allowed the development of biologically active principles that act selectively and specifically in several skin pathologies and subcutaneous tissues, being the natural and safe alternative to classical chemical molecules. Active ingredients Keratinase PB333 Origin: Bacillus Licheniformis. Mechanism of action: Degradation of keratin. Effects: Keratolytic. Acts as the core of the Smart Peeling effect, which recognizes the needs of the skin and acts where it is needed. With its selective technology, it naturally promotes cell renewal and gently, yet effectively, exfoliates the skin without causing irritation. It increases permeability and improves the penetration of other active ingredients. Hyaluronidase PB3000 Origin: Streptococcus Pyogenes. Mechanism of action: Degradation of polysaccharides. Effects: Draining. Corrects complications after hyaluronic acid filler injections. Degrades excess polysaccharides responsible for fluid retention, increasing dermal permeability, and promoting lymphatic drainage. It improves microcirculation and skin appearance, helping to achieve a slimmer figure. Collagenase GH PB220 Origin: Clostridium Histolyticum. Mechanism of action: Degradation of collagen fibers. Effects: Anti-fibrotic. Promotes the regeneration and reorganization of collagen fibers in the dermis, improving the texture and appearance of the skin as well as increasing its suppleness and tonicity with a powerful firming effect. Lipase PB500 Origin: Thermus Thermophilus. Mechanism of action: Triglyceride degradation. Effects: Lipolytic. Activates lipid metabolism within the adipocyte, reducing excess volume and localized fat without damaging the tissue. Eliminates excess sebum at a superficial level, leaving the skin clean, improving its appearance and texture, while facilitating the absorption of active ingredients. Lyase PB72K Origin: Streptococcus Pyogenes. Mechanism of action: Proteoglycan degradation. Effects: Draining. It increases tissue permeability and penetration of collagenase and lipase. Also, it degrades the molecules responsible for the retention of liquids and toxins of the extracellular matrix, reducing body volume and improving the skin’s appearance. Source: https://pbserum.com/enzymes/recombinant-enzymes/

Recombinant Enzymes Pbserum recombinant enzymes are the result of years of biotechnological research by specialized biologists, biochemists, and engineers in our laboratories based in Albacete, Spain. Seeking to boost the regenerative power of enzymes, our group of expert scientists developed the unique technology of Pbserum, which has transformed the way various skin diseases and disorders are managed in clinical practice all over the world. Being a true revolution in global medicine, Pbserum has opened countless therapeutic possibilities to doctors, specialists, and of course, to patients. Biotechnological active principles that act in synergy with recombinant enzymes: o Vitamin A Works in synergy with keratinase to reduce hyperkeratosis and promote cell renewal. Reduces the excessive production of sebum which is responsible for acne breakouts. Stimulates the production of endogenous collagen and helps to maintain correct moisture levels in the dermis. o Vitamin B complex The complex of vitamins B1, B3, B5, and B6 act on the different problems associated with oily skin, thanks to its sebum-regulating, anti-inflammatory and skin-barrier repairing action. Minimizes the appearance of pores and comedones and revitalizes the skin. o Vitamin C A powerful antioxidant that prevents and delays the cellular aging process. Stimulates the production of collagen in the skin, improving its firmness and inhibiting melanin production, reducing the appearance of spots and providing luminosity to the skin. It also helps treat small inflammatory processes. o Vitamin E Lipophilic antioxidant that neutralizes free radicals caused by UV radiation and other external agents. Stimulates cell growth in the dermis and increases water retention at the cellular level. o DMAE It is a natural antioxidant with an immediate lifting effect. Improves the tone and the elasticity of the skin, reducing expression lines. o Hyaluronic acid Low molecular weight hyaluronic acid can penetrate the deep layers of the skin. Fills in wrinkles, fine lines and improves cell cohesion, by inhibiting trans epidermal water loss. Technology Pbserum enzymes are of bacterial origin and were developed through a complex biotechnological process exclusive to Pbserum. A key factor is the use of genetic DNA recombination technology, known as recombinant technology, to obtain enzymes synthesized by bacterial microorganisms, yet have the same structure and sequence as the human enzyme. Thanks to this, procedures based on recombinant enzymes offer a low level of immunogenicity, allowing a safe, effective, pure, and biological treatment. Lyophilization is a dehydration method of the active ingredients by rapid freezing and subsequent sublimation of the ice formed under reduced pressure conditions. A product of high purity and safety is then obtained. This method achieves high stability of the active principles, reserving 100% of the enzymes ’and vitamins’ activity and properties while avoiding the need to use preservatives and additives. Microemulsions are oily solutions that are obtained by the union of two immiscible liquids with a very small-sized particle. This stabilizes enzymes in microcapsules to improve their penetration efficiently and safely. Additionally, the texture of this type of formulation facilitates massaging, without leaving residues and helps to obtain optimal results. ¬¬¬ Efficacy pbserum’s recombinant enzymes base their efficacy on their high specificity and substrate selectivity, as well as on the important role they play in tissue regeneration mechanisms. Through pbserum enzymes, we have managed to enhance this regenerative function and thereby improve the condition of one of the most complex organs that contributes the most to general health: the skin. Using the appropriate recombinant enzyme or the ideal combination of enzymes, as well as the correct therapeutic application, it is possible to reduce skin damage in an accelerated way, including aging signs (wrinkles, expression lines, flaccidity, hyperpigmentation), blemishes, sequelae of acne, scars, fibrosis, cellulite and localized fat, among others. ¬¬¬ ¬ Source: https://pbserum.com/enzymes/recombinant-enzymes/